Causality in Quantiles and Dynamic Stock Return-Volume Relations

This paper investigates the causal relations between stock return and volume based on quantile regressions. We first define Granger non-causality in all quantiles and propose testing non-causality by a sup-Wald test. Such a test is consistent against any deviation from non-causality in distribution, as opposed to the existing tests that check only noncausality in certain moment. This test is readily extended to test non-causality in different quantile ranges, and the testing results enable us to identify the quantile range for which causality is relevant. In the empirical studies of 3 major stock market indices, we find that, while the conventional test suggests no causality in mean, there are strong evidences that lagged volume Granger causes return in all but some middle quantiles. In particular, the causal effects have opposite signs at lower and upper quantiles and are stronger at more extreme quantiles. These relations form (symmetric) V shapes across quantiles. They also show that the dispersion of the return distribution increases with volume so that volume has a positive effect on return volatility. It is also shown that the quantile causal effects of lagged return on volume are mainly negative.Granger non-causality in quantiles, quantile causal effect, quantile regression, return-volume relation, sup-Wald test

Enhancing Automatic Chinese Essay Scoring System from Figures-of-Speech

PACLIC 20 / Wuhan, China / 1-3 November, 200

Investigation of Structural Dynamics of Enzymes and Protonation States of Substrates Using Computational Tools.

This review discusses the use of molecular modeling tools, together with existing experimental findings, to provide a complete atomic-level description of enzyme dynamics and function. We focus on functionally relevant conformational dynamics of enzymes and the protonation states of substrates. The conformational fluctuations of enzymes usually play a crucial role in substrate recognition and catalysis. Protein dynamics can be altered by a tiny change in a molecular system such as different protonation states of various intermediates or by a significant perturbation such as a ligand association. Here we review recent advances in applying atomistic molecular dynamics (MD) simulations to investigate allosteric and network regulation of tryptophan synthase (TRPS) and protonation states of its intermediates and catalysis. In addition, we review studies using quantum mechanics/molecular mechanics (QM/MM) methods to investigate the protonation states of catalytic residues of β-Ketoacyl ACP synthase I (KasA). We also discuss modeling of large-scale protein motions for HIV-1 protease with coarse-grained Brownian dynamics (BD) simulations

Modelling of Hysteresis in Vibration Control Systems by means of the Bouc-Wen Model

The review presents developments concerning the modelling of vibration control systems with hysteresis. In particular, the review focuses on applications of the Bouc-Wen model that describes accurate hysteretic behaviour in vibration control devices. The review consists of theoretical aspects of the Bouc-Wen model, identification procedures, and applications in vibration control

Mechanism of PhosphoThreonine/Serine Recognition and Specificity for Modular Domains from All-atom Molecular Dynamics

<p>Abstract</p> <p>Background</p> <p>Phosphopeptide-binding domains mediate many vital cellular processes such as signal transduction and protein recognition. We studied three well-known domains important for signal transduction: BRCT repeats, WW domain and forkhead-associated (FHA) domain. The first two recognize both phosphothreonine (pThr) and phosphoserine (pSer) residues, but FHA has high specificity for pThr residues. Here we used molecular dynamics (MD) simulations to reveal how FHA exclusively chooses pThr and how BRCT and WW recognize both pThr/pSer. The work also investigated the energies and thermodynamic information of intermolecular interactions.</p> <p>Results</p> <p>Simulations carried out included wide-type and mutated systems. Through analysis of MD simulations, we found that the conserved His residue defines dual loops feature of the FHA domain, which creates a small cavity reserved for only the methyl group of pThr. These well-organized loop interactions directly response to the pThr binding selectivity, while single loop (the 2nd phosphobinding site of FHA) or in combination with α-helix (BRCT repeats) or β-sheet (WW domain) fail to differentiate pThr/pSer.</p> <p>Conclusions</p> <p>Understanding the domain pre-organizations constructed by conserved residues and the driving force of domain-phosphopeptide recognition provides structural insight into pThr specific binding, which also helps in engineering proteins and designing peptide inhibitors.</p

3D Reconstruction from IR Thermal Images and Reprojective Evaluations

Infrared thermography has been widely used in various domains to measure the temperature distributions of objects and surfaces. The methodology can be further extended to 3D applications if the spatial information of the temperature distribution is available. This paper proposes a 3D infrared imaging approach based on silhouette volume intersection to reconstruct volumetric temperature data of enclosed objects. 3D IR images are taken from various angles and integrated with 2D RGB images to effectively reconstruct a 3D model of the object's temperature distributions. Various automatic thresholding methods are also compared and evaluated by reprojection scoring to systematically assess the effectiveness and accuracy of the different approaches. Experiment results have demonstrated the ability of the system to provide an estimate to the 3D location of an internal heat source from images taken externally

Dynamic region of interest transcoding for multipoint video conferencing

This paper presents a region of interest transcoding scheme for multipoint video conferencing to enhance the visual quality. In a multipoint videoconference, usually there are only one or two active conferees at one time which are the regions of interest to the other conferees involved. We propose a Dynamic Sub-Window Skipping (DSWS) scheme to firstly identify the active participants from the multiple incoming encoded video streams by calculating the motion activity of each sub-window, and secondly reduce the frame-rates of the motion inactive participants by skipping these less-important subwindows. The bits saved by the skipping operation are reallocated to the active sub-windows to enhance the regions of interest. We also propose a low-complexity scheme to compose and trace the unavailable motion vectors with a good accuracy in the dropped inactive sub-windows after performing the DSWS. Simulation results show that the proposed methods not only significantly improve the visual quality on the active subwindows without introducing serious visual quality degradation in the inactive ones, but also reduce the computational complexity and avoid whole-frame skipping. Moreover, the proposed algorithm is fully compatible with the H.263 video coding standard. 1